Toltrazuril sulfone

• CAT Number: I004592
• CAS Number: 69004-04-2
• Molecular Formula: C18H14F3N3O6S
• Molecular Weight: 457.38
• Purity: ≥95%
• Target: Antibiotic
• Solubility: DMSO: ≥ 33 mg/mL
• Storage: Store at -20°C

Toltrazuril sulfone is an antiprotozoal agent that acts upon Coccidia parasites.IC50 Value:Target: AntiparasiticPonazuril (INN, Toltrazuril sulfone), sold by the Bayer Corporation under the trade name Marquis, is a drug currently approved for the treatment of equine protozoal myeloencephalitis in horses, caused by Sarcocystis neurona. More recently, veterinarians have been preparing a formulary version of the medication for use in small animals such as cats and dogs against coccidia, an intestinal parasite. Coccidia treatment is far shorter than treatment for EPM. Ponazuril (INN, Toltrazuril sulfone) is useful for Antiprotozoal.

Reference

1:Toltrazuril sulfone sodium salt: synthesis, analytical detection, and pharmacokinetics in the horse. Dirikolu L, Karpiesiuk W, Lehner AF, Tobin T.J Vet Pharmacol Ther. 2012 Jun;35(3):265-74. doi: 10.1111/j.1365-2885.2011.01315.x. Epub 2011 Jun 17. PMID: 21679197 2:Pharmacokinetics of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, after a single oral administration to pigs. Lim JH, Kim MS, Hwang YH, Song IB, Park BK, Yun HI.J Vet Med Sci. 2010 Aug;72(8):1085-7. Epub 2010 Mar 24. PMID: 20332592 Free Article3:Plasma disposition of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, in rabbits after oral administration. Kim MS, Lim JH, Hwang YH, Park BK, Song IB, Yun HI.Vet Parasitol. 2010 Apr 19;169(1-2):51-6. doi: 10.1016/j.vetpar.2009.12.011. Epub 2009 Dec 22. PMID: 20083354 4:Detection, quantifications and pharmacokinetics of toltrazuril sulfone (Ponazuril) in cattle. Dirikolu L, Yohn R, Garrett EF, Chakkath T, Ferguson DC.J Vet Pharmacol Ther. 2009 Jun;32(3):280-8. doi: 10.1111/j.1365-2885.2008.01039.x. PMID: 19646093 5:Synthesis and detection of toltrazuril sulfone and its pharmacokinetics in horses following administration in dimethylsulfoxide. Dirikolu L, Karpiesiuk W, Lehner AF, Hughes C, Granstrom DE, Tobin T.J Vet Pharmacol Ther. 2009 Aug;32(4):368-78. doi: 10.1111/j.1365-2885.2008.01053.x. PMID: 19614842 6:An explorative study to assess the efficacy of toltrazuril-sulfone (ponazuril) in calves experimentally infected with Neospora caninum. Kritzner S, Sager H, Blum J, Krebber R, Greif G, Gottstein B.Ann Clin Microbiol Antimicrob. 2002 Oct 18;1:4. PMID: 12437777 Free PMC Article