TNP-470

• CAT Number: I011402
• CAS Number: 129298-91-5
• Molecular Formula: C19H28ClNO6
• Molecular Weight: 401.9
• Purity: ≥95%
• Target: Aminopeptidase
• Solubility: Soluble in DMSO
• Storage: Room temperature
• InChIKey: MSHZHSPISPJWHW-PVDLLORBSA-N
• SMILES: O=C(NC(CCl)=O)O[C@@H]1CC[C@@]2(OC2)[C@]([C@](O3)(C)[C@H]3C/C=C(C)/C)([H])[C@@H]1OC

TNP 470 (CAT: I011402) is an analog of Fumagillin that exhibits strong antiangiogenic properties in vitro studies. Angiogenesis, the formation of new blood vessels from pre-existing ones, plays a crucial role in various physiological and pathological processes, including tumor growth and metastasis. TNP 470 works by inhibiting the growth of blood vessels, thereby restricting the blood supply to tumors and preventing their progression. Its potent antiangiogenic activity has made it a subject of interest in cancer research, as it offers potential for the development of anti-cancer therapies focused on targeting angiogenesis.

Reference

1: Kidoikhammouan S, Seubwai W, Tantapotinan N, Silsirivanit A, Wongkham S,
Sawanyawisuth K, Wongkham C. TNP-470, a methionine aminopeptidase-2 inhibitor,
inhibits cell proliferation, migration and invasion of human cholangiocarcinoma
cells in vitro. Asian Pac J Cancer Prev. 2012;13 Suppl:155-60. PubMed PMID:
23480758.
2: White HM, Acton AJ, Considine RV. The angiogenic inhibitor TNP-470 decreases
caloric intake and weight gain in high-fat fed mice. Obesity (Silver Spring).
2012 Oct;20(10):2003-9. doi: 10.1038/oby.2012.87. Epub 2012 Apr 18. PubMed PMID:
22510957; PubMed Central PMCID: PMC3401363.
3: Hines J, Ju R, Dutschman GE, Cheng YC, Crews CM. Reversal of TNP-470-induced
endothelial cell growth arrest by guanine and guanine nucleosides. J Pharmacol
Exp Ther. 2010 Sep 1;334(3):729-38. doi: 10.1124/jpet.110.169110. Epub 2010 Jun
22. PubMed PMID: 20571059; PubMed Central PMCID: PMC2939662.
4: Segal E, Pan H, Benayoun L, Kopečková P, Shaked Y, Kopeček J, Satchi-Fainaro
R. Enhanced anti-tumor activity and safety profile of targeted nano-scaled HPMA
copolymer-alendronate-TNP-470 conjugate in the treatment of bone malignances.
Biomaterials. 2011 Jul;32(19):4450-63. doi: 10.1016/j.biomaterials.2011.02.059.
Epub 2011 Mar 22. PubMed PMID: 21429572; PubMed Central PMCID: PMC4598046.