For research use only. Not for therapeutic Use.
TMDJ-035(CAT: I040607) is a highly potent and selective inhibitor of ryanodine receptor 2 (RyR2), a calcium release channel predominantly expressed in cardiac muscle cells. With an EC₅₀ of 13 nM, TMDJ-035 effectively suppresses abnormal Ca²⁺ waves and transients in cardiomyocytes harboring RyR2 mutations, without affecting RyR1 or RyR3 isoforms . Structurally, it favors a cis-amide configuration, which is critical for its inhibitory activity . TMDJ-035 serves as a valuable tool for studying RyR2 channel gating mechanisms and holds promise as a candidate for treating RyR2-related cardiac arrhythmias.
| CAS Number | 2681302-83-8 |
| Synonyms | 2-[5-(3,5-difluorophenyl)tetrazol-2-yl]-N-(4-fluorophenyl)-N-methylacetamide |
| Molecular Formula | C16H12F3N5O |
| Purity | ≥95% |
| IUPAC Name | 2-[5-(3,5-difluorophenyl)tetrazol-2-yl]-N-(4-fluorophenyl)-N-methylacetamide |
| InChI | InChI=1S/C16H12F3N5O/c1-23(14-4-2-11(17)3-5-14)15(25)9-24-21-16(20-22-24)10-6-12(18)8-13(19)7-10/h2-8H,9H2,1H3 |
| InChIKey | IRUXEBHABFUBKY-UHFFFAOYSA-N |
| SMILES | CN(C1=CC=C(C=C1)F)C(=O)CN2N=C(N=N2)C3=CC(=CC(=C3)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
