TMC353121

• CAT Number: I005147
• CAS Number: 857066-90-1
• Molecular Formula: C32H42N6O3
• Molecular Weight: 558.71
• Purity: ≥95%
• Synonyms: 2-[[6-[[2-(3-hydroxypropyl)-5-methylanilino]methyl]-2-(3-morpholin-4-ylpropylamino)benzimidazol-1-yl]methyl]-6-methylpyridin-3-olTMC353121; TMC353121
• Target: RSV
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 9.9(pEC50) [1]
• IUPAC Name: 2-[[6-[[2-(3-hydroxypropyl)-5-methylanilino]methyl]-2-(3-morpholin-4-ylpropylamino)benzimidazol-1-yl]methyl]-6-methylpyridin-3-ol
• InChI: InChI=1S/C32H42N6O3/c1-23-6-9-26(5-3-16-39)28(19-23)34-21-25-8-10-27-30(20-25)38(22-29-31(40)11-7-24(2)35-29)32(36-27)33-12-4-13-37-14-17-41-18-15-37/h6-11,19-20,34,39-40H,3-5,12-18,21-22H2,1-2H3,(H,33,36)
• InChIKey: DKORMNNYNRPTBJ-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C=C1)CCCO)NCC2=CC3=C(C=C2)N=C(N3CC4=C(C=CC(=N4)C)O)NCCCN5CCOCC5

TMC353121 (CAT: I005147) is indeed a potent respiratory syncytial virus (RSV) fusion inhibitor. It works by inhibiting the fusion of RSV particles with host cells, thereby preventing viral entry and replication. This mechanism of action makes it a potential candidate for the treatment of RSV infections. TMC353121 has demonstrated antiviral activity against RSV in preclinical studies and may have applications in the development of new therapies for RSV-related respiratory diseases.

Overview of Clinical Research

TMC353121 is a viral fusion protein inhibitors developed by Johnson&Johnson Pharmaceutical Research&Development. 

Reference

1:Antiviral Activity of TMC353121, a Respiratory Syncytial Virus (RSV) Fusion Inhibitor, in a Non-Human Primate Model. Ispas G, Koul A, Verbeeck J, Sheehan J, Sanders-Beer B, Roymans D, Andries K, Rouan MC, De Jonghe S, Bonfanti JF, Vanstockem M, Simmen K, Verloes R.PLoS One. 2015 May 26;10(5):e0126959. doi: 10.1371/journal.pone.0126959. eCollection 2015. PMID: 26010881 Free PMC Article
2:Selection of a respiratory syncytial virus fusion inhibitor clinical candidate. 2. Discovery of a morpholinopropylaminobenzimidazole derivative (TMC353121). Bonfanti JF, Meyer C, Doublet F, Fortin J, Muller P, Queguiner L, Gevers T, Janssens P, Szel H, Willebrords R, Timmerman P, Wuyts K, van Remoortere P, Janssens F, Wigerinck P, Andries K.J Med Chem. 2008 Feb 28;51(4):875-96. doi: 10.1021/jm701284j. Epub 2008 Feb 7. PMID: 18254606