TL12-186

  • CAT Number: I014787
  • CAS Number: 2250025-88-6
  • Molecular Formula: C₄₄H₅₁ClN₁₀O₉S
  • Molecular Weight: 931.46
  • Purity: ≥95%
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TL12-186 (Cat.No:I014787) is a CRBN-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM).

Catalog Number I014787
CAS Number 2250025-88-6
Molecular Formula

C₄₄H₅₁ClN₁₀O₉S

Purity 95%
Reference

[1]. Hai-Tsang Huang, et al. A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. Cell Chem Biol. 2018 Jan 18;25(1):88-99.e6.

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