(+)-TK216

• CAT Number: I045509
• CAS Number: 1903783-77-6
• Molecular Formula: C19H15Cl2NO3
• Molecular Weight: 376.23
• Purity: ≥95%

(+)-TK216 (Cat No.: I045509) is a small-molecule inhibitor designed to disrupt interactions of EWS-FLI1, an oncogenic fusion protein driving Ewing sarcoma. By blocking this aberrant transcription factor complex, (+)-TK216 interferes with gene expression programs critical for tumor cell proliferation and survival. It has shown promising preclinical and clinical activity in targeting Ewing sarcoma and related cancers. Researchers use (+)-TK216 to explore transcriptional dysregulation, oncogenic fusion proteins, and novel therapeutic strategies for hard-to-treat malignancies characterized by fusion-driven oncogenesis and uncontrolled cell growth.

Reference

[1]. Spriano F, et al. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clin Cancer Res. 2019 Aug 15;25(16):5167-5176.
[Content Brief]

[2]. Jean-Michael Vernier, et al. Indolinone compounds and uses thereof. WO2016057698A1.