Tivantinib

• CAT Number: I005412
• CAS Number: 905854-02-6
• Molecular Formula: C₂₃H₁₉N₃O₂
• Molecular Weight: 369.41
• Purity: ≥95%
• Target: c-MET
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IC50: 0.355 μM(Ki)
• InChI: InChI=1S/C23H19N3O2/c27-22-19(16-11-24-18-9-2-1-7-14(16)18)20(23(28)25-22)17-12-26-10-4-6-13-5-3-8-15(17)21(13)26/h1-3,5,7-9,11-12,19-20,24H,4,6,10H2,(H,25,27,28)/t19-,20-/m0/s1
• InChIKey: UCEQXRCJXIVODC-PMACEKPBSA-N
• SMILES: C1CC2=CC=CC3=C2N(C1)C=C3C4C(C(=O)NC4=O)C5=CNC6=CC=CC=C65

Tivantinib (CAT: I005412) is a small-molecule inhibitor of the MET receptor tyrosine kinase, which is involved in signaling pathways related to cell growth, survival, and metastasis. By selectively targeting and inhibiting the MET receptor, tivantinib interferes with MET-dependent cellular processes and inhibits tumor growth and metastasis. It has shown potential in the treatment of various cancers, including non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Tivantinib’s ability to inhibit MET signaling makes it an attractive candidate for targeted therapy, either as a monotherapy or in combination with other anticancer agents, providing a potential treatment option for patients with MET-positive tumors.

Reference

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