Tis108

• CAT Number: H000076
• CAS Number: 1315459-30-3
• PubChem Substance ID: 102359173
• Molecular Formula: C20H21N3O2
• Molecular Weight: 335.4
• Purity: 98%
• Synonyms: 6-phenoxy-1-phenyl-2-(1H-1,2,4-triazol-1-yl)hexan-1-one
• Storage: Store at 0-8 °C
• Analysis method: HPLC
• IUPAC Name: 6-phenoxy-1-phenyl-2-(1,2,4-triazol-1-yl)hexan-1-one
• InChI: InChI=1S/C20H21N3O2/c24-20(17-9-3-1-4-10-17)19(23-16-21-15-22-23)13-7-8-14-25-18-11-5-2-6-12-18/h1-6,9-12,15-16,19H,7-8,13-14H2
• SMILES: C1=CC=CC=C1C(C(CCCCOC2=CC=CC=C2)[N]3C=NC=N3)=O

Tis108(CAS 1315459-30-3) is a triazole-type strigolactone (SL)-biosynthesis inhibitor that reduces the level of 2-epi-5-deoxystrigol in rice. Treatment of TIS108 increased the number of branches and repressed root hair elongation as was observed in SL-deficient mutants, and co-application of GR24, a synthetic SL analog, recovered the TIS108-induced phenotype to that of wild-type.

Reference

1: Bao YZ, Yao ZQ, Cao XL, Peng JF, Xu Y, Chen MX, Zhao SF. Transcriptome analysis of Phelipanche aegyptiaca seed germination mechanisms stimulated by fluridone, TIS108, and GR24. PLoS One. 2017 Nov 3;12(11):e0187539. doi: 10.1371/journal.pone.0187539. eCollection 2017. PubMed PMID: 29099877.
2: Ito S, Umehara M, Hanada A, Yamaguchi S, Asami T. Effects of strigolactone-biosynthesis inhibitor TIS108 on Arabidopsis. Plant Signal Behav. 2013 May;8(5):e24193. doi: 10.4161/psb.24193. Epub 2013 Mar 19. PubMed PMID: 23511201; PubMed Central PMCID: PMC3907539.