Tiratricol

• CAT Number: A000706
• CAS Number: 51-24-1
• Molecular Formula: C14H9I3O4
• Molecular Weight: 621.93
• Purity: ≥95%
• Synonyms: 51-24-1; Triac; Triacana; 3,3/’,5-TRIIODOTHYROACETIC ACID; Tiratricolum
• Storage: 3 years -20C powder
• InChI: 1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)
• InChIKey: UOWZUVNAGUAEQC-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(=O)O)I)I)O

Tiratricol, also known as TRIAC or triiodothyroacetic acid, is a thyroid hormone analogue. Triiodothyroacetic acid is also a physiologic thyroid hormone that is present in the normal organism in low concentrations. Tiratricol has also been widely marketed, under various trade names, as a weight loss aid. In 1999 and 2000, the United States Food and Drug Administration and Health Canada both issued warnings to the public regarding the use of dietary supplements containing tiratricol.

Reference

1: Cohen-Lehman J, Charitou MM, Klein I. Tiratricol-induced periodic paralysis: a
review of nutraceuticals affecting thyroid function. Endocr Pract. 2011
Jul-Aug;17(4):610-5. doi: 10.4158/EP10137.RA. Review. PubMed PMID: 21803722.

2: Cascales L, Mas-Moruno C, Tamborero S, Aceña JL, Sanz-Cervera JF, Fustero S,
Cruz LJ, Mora P, Albericio F, Pérez-Payá E. Tiratricol neutralizes bacterial
endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the
cell. Chem Biol Drug Des. 2008 Oct;72(4):320-8. doi:
10.1111/j.1747-0285.2008.00703.x. PubMed PMID: 18844678.

3: Ma RC, Chan MH, Poon WT, So WY, Chow CC. Thyroid dysfunction due to
over-the-counter usage of tiratricol. Intern Med J. 2008 Jul;38(7):611-2. doi:
10.1111/j.1445-5994.2008.01708.x. PubMed PMID: 18715309.

4: Ephedrine and tiratricol: freshly prepared mixtures forbidden in France.
Prescrire Int. 2004 Apr;13(70):58. PubMed PMID: 15148977.

5: Scally MC, Hodge A. A report of hypothyroidism induced by an over-the-counter
fat loss supplement (Tiratricol). Int J Sport Nutr Exerc Metab. 2003
Mar;13(1):112-6. PubMed PMID: 12660410.

6: Bauer BA, Elkin PL, Erickson D, Klee GG, Brennan MD. Symptomatic
hyperthyroidism in a patient taking the dietary supplement tiratricol. Mayo Clin
Proc. 2002 Jun;77(6):587-90. PubMed PMID: 12059130.

7: Sherman SI, Ringel MD, Smith MJ, Kopelen HA, Zoghbi WA, Ladenson PW. Augmented
hepatic and skeletal thyromimetic effects of tiratricol in comparison with
levothyroxine. J Clin Endocrinol Metab. 1997 Jul;82(7):2153-8. PubMed PMID:
9215287.

8: Sherman SI, Ladenson PW. Organ-specific effects of tiratricol: a thyroid
hormone analog with hepatic, not pituitary, superagonist effects. J Clin
Endocrinol Metab. 1992 Sep;75(3):901-5. PubMed PMID: 1517383.

9: Archambeaud-Mouveroux F, Treves R, Veira JC, Laurent M. [Side-effects of
tiratricol. Apropos of 4 cases]. Therapie. 1986 Nov-Dec;41(6):519-20. French.
PubMed PMID: 3810549.

10: Jean-Pastor MJ, Jean P, Biour M, Castot A, Chichmanian F, Danan G, Levy VG,
Sarles H. [Hepatopathies from treatment with a specialty drug combination of
tiratricol-cyclovalone-retinol]. J Toxicol Clin Exp. 1986 Mar-Apr;6(2):115-21.
French. PubMed PMID: 3783484.