Tipiracil

• CAT Number: I002374
• CAS Number: 183204-74-2
• Molecular Formula: C9H11ClN4O2
• Molecular Weight: 242.66
• Purity: ≥95%
• Target: thymidine phosphorylase[1]
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C

 Tipiracil (Cat.No:I002374) increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. The combination of Trifluridine and Tipiracil is a new oral treatment approved for patients with metastatic colorectal cancer.

Reference

[1]. Lee SJ, et al. Thymidine phosphorylase influences [(18)F]fluorothymidine uptake in cancer cells and patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1327-35.

[2]. Raedler LA. Lonsurf (Trifluridine plus Tipiracil): A New Oral Treatment Approved for Patients with Metastatic Colorectal Cancer. Am Health Drug Benefits. 2016 Mar;9(Spec Feature):97-100.

[3]. Tanaka N, et al. Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models. Oncol Rep. 2014 Dec;32(6):2319-26.