Tildipirosin- CAS 328898-40-4

Tildipirosin(Zuprevo) is a novel 16-membered macrolide for treatment, control, and prevention of bovine respiratory disease; inhibits protein synthesis on the ribosome (IC50= 0.23 ± 0.01 μM).
IC50 value:
Target: Antibiotic; Protein synthesis inhibitor
The efficacy of tildipirosin at inhibiting protein synthesis on the ribosome is 50% inhibitory concentration [IC(50)], 0.23 ± 0.01 μM [1]. The time-concentration profile of tildipirosin in BF and lung far exceeded that in blood plasma. In lung, tildipirosin concentrations reached 3.1 μg/g at 2 h, peaked at 4.3 μg/g at day 1, and slowly declined to 0.8 μg/g at day 17. In BF, tildipirosin levels were 14.3, 7.0, and 6.5 μg/g at days 5, 10, and 14. T1/2 in lung was ~7 days. Tildipirosin is rapidly and extensively distributed to the respiratory tract followed by slow elimination [2].

Catalog Number: I003170

CAS Number: 328898-40-4

PubChem Substance ID:355038984

Molecular Formula: C₄₁H₇₁N₃O₈

Molecular Weight:734.03

Purity: ≥95%

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* For research use only. Not for human or veterinary use.

Synonym

Synonyms20-deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-β-D-glucopyranosyl]-20,23-di-1-piperidinyl-tylonolide

Property

Molecular Formula: C₄₁H₇₁N₃O₈
Molecular Weight734.03
Target:Antibiotic; Protein synthesis inhibitor
Solubility10 mM in DMSO
Purity≥95%
Storage-20°C

Computed Descriptor

InChIInChI=1S/C41H71N3O8/c1-8-35-32(26-44-20-13-10-14-21-44)23-27(2)15-16-33(45)28(3)24-31(17-22-43-18-11-9-12-19-43)40(29(4)34(46)25-36(47)51-35)52-41-39(49)37(42(6)7)38(48)30(5)50-41/h15-16,23,28-32,34-35,37-41,46,48-49H,8-14,17-22,24-26H2,1-7H3/b16-15+,27-2
InChIKeyHNDXPZPJZGTJLJ-UEJFNEDBSA-N
SMILESCCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)O)N(C)C)O)CCN3CCCCC3)C)C)CN4CCCCC4