Ticagrelor-d7

• CAT Number: R013483
• CAS Number: 1265911-55-4
• Molecular Formula: C23H21D7F2N6O4S
• Molecular Weight: 529.615
• Purity: ≥95%
• Storage: -20°C
• Related CAS: 274693-27-5 (unlabelled)
• IUPAC Name: (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(1,1,2,2,3,3,3-heptadeuteriopropylsulfanyl)triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
• InChI: InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1/i1D3,2D2,7D2
• InChIKey: OEKWJQXRCDYSHL-MHTCSOGVSA-N
• SMILES: CCCSC1=NC2=C(C(=N1)NC3CC3C4=CC(=C(C=C4)F)F)N=NN2C5CC(C(C5O)O)OCCO

Ticagrelor-d7(CAS1265911-55-4)is intended for use as an internal standard for the quantification of ticagrelor by GC- or LC-MS. Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12receptor (Ki= 14 nM; IC50= 1.8 M), which is the main receptor responsible for ADP-induced platelet aggregation.It functions by directly changing the conformation of the P2Y12receptor to inhibit ADP binding.Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.

Reference

1.Zech, Gernot, et al. "Identification of high-affinity P2Y12 antagonists based on a phenylpyrazole glutamic acid piperazine backbone." Journal of medicinal chemistry 55.20 (2012): 8615-8629.
2.Michelson, Alan D. "Advances in antiplatelet therapy." Hematology 2010, the American Society of Hematology Education Program Book 2011.1 (2011): 62-69.
3.Wallentin, Lars. "P2Y12 inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use." European heart journal 30.16 (2009): 1964-1977.