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THZ1 Hydrochloride

THZ1 Hydrochloride

  • CAT Number: I005773
  • Molecular Formula: C31H29Cl2N7O2
  • Molecular Weight: 602.51
  • Purity: ≥95%
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THZ1 Hydrochloride&nbsp;is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell/’s proliferation with IC50 of 50 nM.&nbsp;
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Catalog Number I005773
Synonyms

(E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(4-(dimethylamino)but-2-enamido)benzamide hydrochloride

Molecular Formula

C31H29Cl2N7O2

Purity 95%
Target Cyclin-Dependent Kinases
Solubility >30.1mg/mL in DMSO
Storage Store at -20°C
IC50 3.2 nM (Kd for CDK7)
SMILES ClC(C=N1)=C(C2=CNC3=C2C=CC=C3)N=C1NC4=CC(NC(C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5)=O)=CC=C4.Cl
Reference

[1]. Nicholas Kwiatkowski, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature (2014) doi:10.1038/nature13393

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