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Thiol-PEG4-acid

Thiol-PEG4-acid

  • CAT Number: I016373
  • CAS Number: 749247-06-1
  • Molecular Formula: C₁₁H₂₂O₆S
  • Molecular Weight: 282.35
  • Purity: ≥95%
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Thiol-PEG4-acid(CAT: I016373) is a PEG-based linker commonly employed in the synthesis of PROTACs (PROteolysis TAgeting Chimeras). PROTACs are innovative molecules designed to induce targeted protein degradation. The thiol group in Thiol-PEG4-acid can serve as a point of attachment for ligands that interact with specific target proteins. This linker allows for the connection between the target protein and an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent proteasomal degradation of the target protein.

Catalog Number I016373
CAS Number 749247-06-1
Molecular Formula

C₁₁H₂₂O₆S

Purity 95%
Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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