thiethylperazine

• CAT Number: M050663
• CAS Number: 1420-55-9
• Molecular Formula: C22H29N3S2
• Molecular Weight: 399.615
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: 2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine
• InChI: InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3
• InChIKey: XCTYLCDETUVOIP-UHFFFAOYSA-N
• SMILES: CCSC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCN(CC4)C

Thiethylperazine is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects. Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice.

Reference

1:[Noncardiogenic pulmonary edema in the course of poisoning with clozapine, ketoprofen and thiethylperazine]. Majewska M, Kołodziej M, Szponar J, Drelich G, Danielewicz P, Kostek H.Przegl Lek. 2012;69(8):618-20. Polish. PMID: 23243946 2:Anaphylactic reaction and unrelated, subsequent, known side effects during therapy with thiethylperazine. Rossetti G, Livio F, Roulet E, Hofer MF.Pediatr Allergy Immunol. 2005 Aug;16(5):453-5. PMID: 16101941 3:Thiethylperazine-induced parkinsonism: in vivo demonstration of dopamine D2 receptors blockade. Briani C, Cagnin A, Chierichetti F, Tiberio M, Battistin L, Pizzolato G.Eur J Neurol. 2004 Oct;11(10):709-10. PMID: 15469457 4:Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. Czeizel AE, Vargha P.BJOG. 2003 May;110(5):497-9. PMID: 12742335 Free Article5:Subacute cutaneous lupus erythematosus associated with cinnarizine and thiethylperazine therapy. Toll A, Campo-Pisa P, González-Castro J, Campo-Voegeli A, Azón A, Iranzo P, Lecha M, Herrero C.Lupus. 1998;7(5):364-6. PMID: 9696142 6:Incompatibility of ketorolac tromethamine with haloperidol lactate and thiethylperazine maleate. Mendenhall A, Hoyt DB.Am J Hosp Pharm. 1994 Dec 1;51(23):2964. No abstract available. PMID: 7879809 7:[Dyskinesis after a single dose of thiethylperazine during the first trimester of pregnancy]. Budrewicz S, Ejma M.Pol Tyg Lek. 1994 Feb 21-28;49(8-9):205-6. Polish. PMID: 8084830 8:Thiethylperazine treatment of gastroparesis diabeticorum. Lossos IS, Mevorach D, Oren R.Ann Pharmacother. 1992 Jul-Aug;26(7-8):1016. No abstract available. PMID: 1504386 9:Chronic hemidystonia following acute dystonic reaction to thiethylperazine. Jiménez-Jiménez FJ, Vazquez A, Garcia-Ruiz P, Garcia-Urra D, De Seijas EV.J Neurol Neurosurg Psychiatry. 1991 Jun;54(6):562. No abstract available. PMID: 1880525 Free PMC Article10:The antiemetic efficacy of thiethylperazine and methylprednisolone versus thiethylperazine and placebo in breast cancer patients treated with adjuvant chemotherapy (fluorouracil, doxorubicin and cyclophosphamide). A randomized, double-blind, cross-over trial. Diaz-Rubio E, Martin M, Rosell R, Valerdi JJ, Gonzalez-Larriba JL, Barriga JJ.Acta Oncol. 1991;30(3):339-42. PMID: 2036244