Thiarabine

• CAT Number: I009795
• CAS Number: 26599-17-7
• Molecular Formula: C9H13N3O4S
• Molecular Weight: 259.28
• Purity: ≥95%
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidin-2-one
• InChI: InChI=1S/C9H13N3O4S/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
• InChIKey: GAKJJSAXUFZQTL-CCXZUQQUSA-N
• SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(S2)CO)O)O

Thiarabine (Cat.No:I009795) is an antiviral nucleoside analog with potential applications in the treatment of viral infections. It is a sulfur-substituted derivative of cytarabine, and its unique structure enhances its antiviral activity. Thiarabine has been studied for its efficacy against various viral pathogens, including herpes simplex virus and human immunodeficiency virus (HIV).

Reference

1:Thiarabine, 1-(4-Thio-β-D-arabinofuranosyl)cytosine. A Deoxycytidine Analog With Excellent Anticancer Activity. Parker WB, Waud WR, Secrist JA 3rd.Curr Med Chem. 2015;22(34):3881-96. Review. PMID: 26597061 2:Preclinical antitumor activity of thiarabine in human leukemia and lymphoma xenograft models. Waud WR, Gilbert KS, Secrist JA 3rd.Nucleosides Nucleotides Nucleic Acids. 2012;31(9):647-60. PMID: 23004929 3:Preclinical combination therapy of thiarabine plus various clinical anticancer agents. Waud WR, Gilbert KS, Secrist JA 3rd.Nucleosides Nucleotides Nucleic Acids. 2012;31(8):630-46. doi: 10.1080/15257770.2012.712181. PMID: 22908953 4:Isolation and characterization of a murine P388 leukemia line resistant to thiarabine. Waud WR, Parker WB, Gilbert KS, Secrist JA.Nucleosides Nucleotides Nucleic Acids. 2012;31(1):14-27. doi: 10.1080/15257770.2011.637099. PMID: 22257207