Thalidomide-O-PEG4-NHS ester

For research use only. Not for therapeutic Use.

  • CAT Number: I015697
  • CAS Number: 2411681-88-2
  • Molecular Formula: C28H33N3O13
  • Molecular Weight: 619.57
  • Purity: ≥95%
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Thalidomide-O-PEG4-NHS ester(Cat No.:I015697)is a functionalized thalidomide derivative designed for PROTAC (proteolysis-targeting chimera) and chemical biology research. The thalidomide moiety binds cereblon (CRBN), an E3 ubiquitin ligase component, enabling targeted protein degradation. Its PEG4 linker provides flexibility, solubility, and reduced steric hindrance, optimizing conjugation efficiency. The NHS ester group offers a reactive site for coupling with primary amines, facilitating attachment to protein ligands, peptides, or other molecules. Thalidomide-O-PEG4-NHS ester is widely used in medicinal chemistry to construct bifunctional degraders and explore therapeutic strategies in targeted protein degradation.


CAS Number 2411681-88-2
Synonyms

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]propanoate

Molecular Formula C28H33N3O13
Purity ≥95%
IUPAC Name (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]propanoate
InChI InChI=1S/C28H33N3O13/c32-21-5-4-19(26(36)29-21)30-27(37)18-2-1-3-20(25(18)28(30)38)43-17-16-42-15-14-41-13-12-40-11-10-39-9-8-24(35)44-31-22(33)6-7-23(31)34/h1-3,19H,4-17H2,(H,29,32,36)
InChIKey ITOQEZXJMMXWEQ-UHFFFAOYSA-N
SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCOCCOCCOCCOCCC(=O)ON4C(=O)CCC4=O
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