TH5427

For research use only. Not for therapeutic Use.

  • CAT Number: I043731
  • CAS Number: 2253744-56-6
  • Molecular Formula: C20H20Cl2N8O3
  • Molecular Weight: 491.33
  • Purity: ≥95%
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TH5427(Cat No.:I043731)is a potent, selective inhibitor targeting the enzyme CDK7 (Cyclin-Dependent Kinase 7), a key regulator in the cell cycle and transcriptional regulation. By inhibiting CDK7, TH5427 disrupts the transcriptional machinery and cell cycle progression, leading to cancer cell death. This compound is particularly effective against cancers with high levels of CDK7 activity, such as certain types of leukemia and solid tumors. TH5427 shows potential as a therapeutic agent in oncology, offering a novel approach to target tumor growth and proliferation by disrupting key regulatory pathways.


CAS Number 2253744-56-6
Synonyms

7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-piperazin-1-ylpurine-2,6-dione

Molecular Formula C20H20Cl2N8O3
Purity ≥95%
IUPAC Name 7-[[5-(3,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-piperazin-1-ylpurine-2,6-dione
InChI InChI=1S/C20H20Cl2N8O3/c1-27-16-15(18(31)28(2)20(27)32)30(19(24-16)29-7-5-23-6-8-29)10-14-25-26-17(33-14)11-3-4-12(21)13(22)9-11/h3-4,9,23H,5-8,10H2,1-2H3
InChIKey QXCXMVYVUHVFLP-UHFFFAOYSA-N
SMILES CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)N3CCNCC3)CC4=NN=C(O4)C5=CC(=C(C=C5)Cl)Cl
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