RSU 1131

• CAT Number: I035758
• CAS Number: 88876-89-5
• Molecular Formula: C9H14N4O3
• Molecular Weight: 226.23
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1-(2-methylaziridin-1-yl)-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol
• InChI: InChI=1S/C9H14N4O3/c1-7-4-12(7)6-8(14)5-11-3-2-10-9(11)13(15)16/h2-3,7-8,14H,4-6H2,1H3
• InChIKey: AFLZZBWHQVDQKY-UHFFFAOYSA-N
• SMILES: OC(CN1C(C)C1)CN2C=CN=C2[N+]([O-])=O

RSU 1131 is a nitroimidazole-aziridine.

Reference

1: O’Neill P, McNeil SS, Jenkins TC. Induction of DNA crosslinks in vitro upon reduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131. Biochem Pharmacol. 1987 Jun 1;36(11):1787-92. PubMed PMID: 3579973.
2: Jenner TJ, Sapora O, O’Neill P, Fielden EM. Enhancement of DNA damage in mammalian cells upon bioreduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131. Biochem Pharmacol. 1988 Oct 15;37(20):3837-42. PubMed PMID: 3190731.
3: Sapora O, Paone A, Maggi A, Jenner TJ, O’Neill P. Induction of mutations in V79-4 mammalian cells under hypoxic and aerobic conditions by the cytotoxic 2-nitroimidazole-aziridines, RSU-1069 and RSU-1131. The influence of cellular glutathione. Biochem Pharmacol. 1992 Oct 6;44(7):1341-7. PubMed PMID: 1417957.
4: Walling J, Stratford IJ, Adams GE, Stephens MA. Dual-function radiation sensitizers and bioreductive drugs: factors affecting cellular uptake and sensitizing efficiency in analogues of RSU 1069. Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Apr;53(4):641-9. PubMed PMID: 3258298.