TH-Z145

• CAT Number: I042612
• CAS Number: 2260887-57-6
• Molecular Formula: C16H28O7P2
• Molecular Weight: 394.34
• Purity: ≥95%
• Synonyms: [2-(3-octoxyphenyl)-1-phosphonoethyl]phosphonic acid
• InChI: InChI=1S/C16H28O7P2/c1-2-3-4-5-6-7-11-23-15-10-8-9-14(12-15)13-16(24(17,18)19)25(20,21)22/h8-10,12,16H,2-7,11,13H2,1H3,(H2,17,18,19)(H2,20,21,22)
• InChIKey: PHLMZTHHBLJPRI-UHFFFAOYSA-N
• SMILES: CCCCCCCCOC1=CC=CC(=C1)CC(P(=O)(O)O)P(=O)(O)O

TH-Z145 (Cat No.: I042612) is a selective inhibitor of KRAS G12D, a common oncogenic mutant of the KRAS protein implicated in various cancers, including pancreatic and colorectal cancers. By covalently binding to the mutant KRAS G12D, TH-Z145 disrupts downstream signaling pathways such as MAPK and PI3K, which are essential for tumor growth and survival. It exhibits high specificity and potency, making it a promising tool for studying mutant KRAS-driven oncogenesis. TH-Z145 supports the development of targeted therapies against hard-to-treat KRAS-mutant cancers.

Reference

[1]. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21.
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