CJOC42

• CAT Number: I024843
• CAS Number: 2171519-89-2
• Molecular Formula: C20H21N3O5S
• Molecular Weight: 415.46
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: Methyl 4-(4-(3-(tosyloxy)propyl)-1H-1,2,3-triazol-1-yl)benzoate
• InChI: InChI=1S/C20H21N3O5S/c1-15-5-11-19(12-6-15)29(25,26)28-13-3-4-17-14-23(22-21-17)18-9-7-16(8-10-18)20(24)27-2/h5-12,14H,3-4,13H2,1-2H3
• InChIKey: VYUDJPGSULLWAS-UHFFFAOYSA-N
• SMILES: O=C(OC)C1=CC=C(N2N=NC(CCCOS(=O)(C3=CC=C(C)C=C3)=O)=C2)C=C1

CJOC42 binds to and inhibits gankyrin activity in a dose-dependent manner. Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. Cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin, and it restores p53-dependent transcription and sensitivity to DNA damage.

Reference

1: Chattopadhyay A, O’Connor CJ, Zhang F, Galvagnion C, Galloway WR, Tan YS, Stokes JE, Rahman T, Verma C, Spring DR, Itzhaki LS. Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Sci Rep. 2016 Apr 5;6:23732. doi: 10.1038/srep23732. PubMed PMID: 27046077; PubMed Central PMCID: PMC4820706.