For research use only. Not for therapeutic Use.
TFMB-(S)-2-HG (Cat No.:I037164) is a cell-permeable derivative of the oncometabolite (S)-2-hydroxyglutarate, designed for enhanced membrane transport and intracellular delivery. It mimics the endogenous metabolite that accumulates in certain IDH-mutant cancers, influencing epigenetic regulation by inhibiting α-ketoglutarate–dependent dioxygenases, including TET DNA demethylases and histone demethylases. TFMB-(S)-2-HG is widely used in cancer biology and epigenetics research to model IDH mutation-driven metabolic and transcriptional changes. Its modified structure enables efficient study of oncometabolite activity in vitro and in vivo, supporting therapeutic development against metabolic and epigenetic dysregulation in cancer.
| CAS Number | 1445703-64-9 |
| Synonyms | [3-(trifluoromethyl)phenyl]methyl (2S)-5-oxooxolane-2-carboxylate |
| Molecular Formula | C13H11F3O4 |
| Purity | ≥95% |
| IUPAC Name | [3-(trifluoromethyl)phenyl]methyl (2S)-5-oxooxolane-2-carboxylate |
| InChI | InChI=1S/C13H11F3O4/c14-13(15,16)9-3-1-2-8(6-9)7-19-12(18)10-4-5-11(17)20-10/h1-3,6,10H,4-5,7H2/t10-/m0/s1 |
| InChIKey | UXTLNUGKDZMPTC-JTQLQIEISA-N |
| SMILES | C1CC(=O)O[C@@H]1C(=O)OCC2=CC(=CC=C2)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
