SPR719

• CAT Number: I018007
• CAS Number: 1384984-18-2
• Molecular Formula: C₂₁H₂₅FN₆O₃
• Molecular Weight: 428.46
• Purity: ≥95%
• IUPAC Name: 1-ethyl-3-[5-fluoro-6-[2-(2-hydroxypropan-2-yl)pyrimidin-5-yl]-4-[(2R)-oxolan-2-yl]-1H-benzimidazol-2-yl]urea
• InChI: InChI=1S/C21H25FN6O3/c1-4-23-20(29)28-19-26-13-8-12(11-9-24-18(25-10-11)21(2,3)30)16(22)15(17(13)27-19)14-6-5-7-31-14/h8-10,14,30H,4-7H2,1-3H3,(H3,23,26,27,28,29)/t14-/m1/s1
• InChIKey: BKUISYCLLXCBJV-CQSZACIVSA-N
• SMILES: CCNC(=O)NC1=NC2=C(N1)C=C(C(=C2C3CCCO3)F)C4=CN=C(N=C4)C(C)(C)O

SPR719（Cat No.:I018007） is a novel, oral, selective inhibitor of the bacterial enzyme DprE1, essential for the synthesis of the cell wall of Mycobacterium tuberculosis (Mtb). It exhibits potent activity against both drug-susceptible and multidrug-resistant Mtb strains, with a minimal inhibitory concentration (MIC) range of 0.03 to 0.5 μg/mL.

Reference

[1]. Locher CP, et al. A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections. Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65.