Tetrandrine

• CAT Number: R014980
• CAS Number: 518-34-3
• Molecular Formula: C38H42N2O6
• Molecular Weight: 622.762
• Purity: ≥95%
• Storage: 3 years -20C powder
• InChI: InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1
• InChIKey: WVTKBKWTSCPRNU-KYJUHHDHSA-N
• SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC

Tetrandrine is a bisbenylisoquinoline alkaloid isolated from the dried root of Stephenia tetrandra S Moore. Tetrandrine exhibits very broad pharmacological actions, including anti-tumor activity. The beneficial effects of tetrandrine on tumor cell cytotoxicity and radiosensitization, multidrug resistance, normal tissue radioprotection, and angiogenesis are most promising and deserve great attention. Tetrandrine has potential either as a tumoricidal agent or as an adjunct to chemotherapy and radiotherapy.

Reference

1:Co-delivery of paclitaxel and tetrandrine via iRGD peptide conjugated lipid-polymer hybrid nanoparticles overcome multidrug resistance in cancer cells. Zhang J, Wang L, Fai Chan H, Xie W, Chen S, He C, Wang Y, Chen M.Sci Rep. 2017 May 4;7:46057. doi: 10.1038/srep46057. PMID: 28470171 Free PMC Article2:Tetrandrine potentiates the glucocorticoid pharmacodynamics via inhibiting P-glycoprotein and mitogen-activated protein kinase in mitogen-activated human peripheral blood mononuclear cells. Xu W, Meng K, Tu Y, Tanaka S, Onda K, Sugiyama K, Hirano T, Yamada H.Eur J Pharmacol. 2017 Apr 11. pii: S0014-2999(17)30249-2. doi: 10.1016/j.ejphar.2017.04.007. [Epub ahead of print] PMID: 28408143 3:Tetrandrine inhibits the proliferation of human osteosarcoma cells by upregulating the PTEN pathway. Tian DD, Zhang RX, Wu N, Yuan W, Luo SH, Chen HQ, Liu Y, Wang Y, He BC, Deng ZL.Oncol Rep. 2017 May;37(5):2795-2802. doi: 10.3892/or.2017.5560. Epub 2017 Apr 6. PMID: 28393256 4:The effect of tetrandrine combined with cisplatin on proliferation and apoptosis of A549/DDP cells and A549 cells. Ye LY, Hu S, Xu HE, Xu RR, Kong H, Zeng XN, Xie WP, Wang H.Cancer Cell Int. 2017 Mar 27;17:40. doi: 10.1186/s12935-017-0410-1. eCollection 2017. PMID: 28360820 Free PMC Article5:Tetrandrine, an agonist of aryl hydrocarbon receptor, reciprocally modulates the activities of STAT3 and STAT5 to suppress Th17 cell differentiation. Yuan X, Dou Y, Wu X, Wei Z, Dai Y.J Cell Mol Med. 2017 Mar 22. doi: 10.1111/jcmm.13141. [Epub ahead of print] PMID: 28332288 Free Article6:Tetrandrine inhibits migration and invasion of human renal cell carcinoma by regulating Akt/NF-κB/MMP-9 signaling. Chen S, Liu W, Wang K, Fan Y, Chen J, Ma J, Wang X, He D, Zeng J, Li L.PLoS One. 2017 Mar 13;12(3):e0173725. doi: 10.1371/journal.pone.0173725. eCollection 2017. PMID: 28288190 Free PMC Article7:Tetrandrine prevents multidrug resistance in the osteosarcoma cell line, U-2OS, by preventing Pgp overexpression through the inhibition of NF-κB signaling. Lu Y, Li F, Xu T, Sun J.Int J Mol Med. 2017 Apr;39(4):993-1000. doi: 10.3892/ijmm.2017.2895. Epub 2017 Feb 17. PMID: 28260091 8:TGF-β1/PTEN/PI3K signaling plays a critical role in the anti-proliferation effect of tetrandrine in human colon cancer cells. Chen QZ, Li Y, Shao Y, Zeng YH, Ren WY, Liu RX, Zhou LY, Hu XL, Huang M, He F, Sun WJ, Wu K, He BC.Int J Oncol. 2017 Mar;50(3):1011-1021. doi: 10.3892/ijo.2017.3875. Epub 2017 Feb 13. PMID: 28197642 9:Design and synthesis of novel tetrandrine derivatives as potential anti-tumor agents against human hepatocellular carcinoma. Lan J, Wang N, Huang L, Liu Y, Ma X, Lou H, Chen C, Feng Y, Pan W.Eur J Med Chem. 2017 Feb 15;127:554-566. doi: 10.1016/j.ejmech.2017.01.008. Epub 2017 Jan 7. PMID: 28109948 10:Synergistic Effects of Tetrandrine with Posaconazole Against Aspergillus fumigatus. Li SX, Song YJ, Jiang L, Zhao YJ, Guo H, Li DM, Zhu KJ, Zhang H.Microb Drug Resist. 2017 Jan 12. doi: 10.1089/mdr.2016.0217. [Epub ahead of print] PMID: 28080217