Tesmilifene fumarate

• CAT Number: I010292
• CAS Number: 1185241-83-1
• Molecular Formula: C23H29NO5
• Molecular Weight: 399.48
• Purity: ≥95%
• Synonyms: 2-(4-benzylphenoxy)-N,N-diethylethanamine;(E)-but-2-enedioic acid
• InChI: InChI=1S/C19H25NO.C4H4O4/c1-3-20(4-2)14-15-21-19-12-10-18(11-13-19)16-17-8-6-5-7-9-17;5-3(6)1-2-4(7)8/h5-13H,3-4,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
• InChIKey: ZOOMDYHTGZSGDD-WLHGVMLRSA-N
• SMILES: CCN(CC)CCOC1=CC=C(C=C1)CC2=CC=CC=C2.C(=C/C(=O)O)\C(=O)O

Tesmilifene fumarate（Cat No.:I010292）is a small-molecule antihistamine derivative with potential anticancer properties. Originally developed as a cytoprotective agent, it functions as a selective modulator of multidrug resistance and enhances the efficacy of chemotherapeutic agents such as anthracyclines. By interfering with drug efflux mechanisms and modulating apoptosis pathways, Tesmilifene fumarate sensitizes tumor cells to chemotherapy while minimizing toxicity in normal tissues. The fumarate salt form improves solubility and stability. In research, it is a valuable tool for studying drug resistance, cancer pharmacology, and strategies to improve chemotherapeutic response.