Teriflunomide

• CAT Number: I002123
• CAS Number: 163451-81-8
• Molecular Formula: C12H9F3N2O2
• Molecular Weight: 270.21
• Purity: ≥95%
• Target: Dehydrogenase
• Solubility: DMSO: ≤ 26 mg/mL
• Storage: Store at -20°C
• IUPAC Name: (Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
• InChI: InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-
• InChIKey: UTNUDOFZCWSZMS-YFHOEESVSA-N
• SMILES: CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O

Teriflunomide（Cat No.:I002123）, also known as A77 1726, is the active metabolite of leflunomide and is used in the research and treatment of rheumatoid arthritis. It exerts its therapeutic effects by inhibiting the enzyme dihydroorotate dehydrogenase (DHODH), a key enzyme involved in pyrimidine synthesis. By blocking pyrimidine synthesis, teriflunomide reduces the proliferation of T-cells and B-cells, which are involved in the inflammatory response seen in rheumatoid arthritis.

Reference

[1]. He D, Xu Z, Dong S, et al. Teriflunomide for multiple sclerosis. Cochrane Database Syst Rev. 2012 Dec 12;12:CD009882.
[2]. Papadopoulou A, Kappos L, Sprenger T. Teriflunomide for oral therapy in multiple sclerosis. Expert Rev Clin Pharmacol. 2012 Nov;5(6):617-28.
[3]. Miller AE, O/’Connor P, Wolinsky JS, et al. Pre-specified subgroup analyses of a placebo-controlled phase III trial (TEMSO) of oral teriflunomide in relapsing multiple sclerosis. Mult Scler. 2012 Nov;18(11):1625-32.
[4]. Xi H, Cun D, Wang Z, et al. Effect of the stability of hydrogen-bonded ion pairs with organic amines on transdermal penetration of teriflunomide. Int J Pharm. 2012 Oct 15;436(1-2):857-61.