Tenovin-3

• CAT Number: I000115
• CAS Number: 1011301-27-1
• Molecular Formula: C18H21N3OS
• Molecular Weight: 327.4
• Purity: ≥95%
• Target: p53
• Solubility: DMSO: ＞ 31 mg/mL
• Storage: Store at -20°C
• IUPAC Name: N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide
• InChI: InChI=1S/C18H21N3OS/c1-18(2,3)13-6-4-12(5-7-13)16(22)21-17(23)20-15-10-8-14(19)9-11-15/h4-11H,19H2,1-3H3,(H2,20,21,22,23)
• InChIKey: NLAXTZPUTNGRDU-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(N)C=C2)=S)=O)C=C1

Tenovin-3n(Cat.No:I000115) is a small molecule compound known for its role as a sirtuin inhibitor. It targets the sirtuin enzymes, affecting various cellular processes like DNA repair and cell cycle regulation. Tenovin-3 has shown potential in preclinical studies as a candidate for cancer therapy due to its ability to induce apoptosis in cancer cells.

Reference

[1]. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.