Tenovin-1

• CAT Number: I003395
• CAS Number: 380315-80-0
• Molecular Formula: C₂₀H₂₃N₃O₂S
• Molecular Weight: 369.48
• Purity: ≥95%
• Target: p53
• Solubility: Soluble to 25 mM in DMSO
• Storage: 3 years -20C powder
• InChI: InChI=1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26)
• InChIKey: WOWJIWFCOPZFGV-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C

Tenovin-1 is a inhibitor of SIRT1 and SIRT2; activator of p21 and p53.IC50 Value:Target: SirtuinTenovin-1 is a compound that belongs to the class of Tenovins, and inhibits SIRT1 and SIRT2. SIRT1 and SIRT2 are protein-deacetylases and are members of the NAD+-dependent class III histone deacetylases. Tenovin-1 has been shown to activate and elevate acetylated p53 levels, induce apoptosis in vitro.in vitro: Tenovin-1 elevates the amount of p53 protein within 2 hr of treatment. This compound also increases the levels of the p53-downstream target p21CIP/WAF1 protein and mRNA, confirming that tenovin-1 can induce expression from an endogenous p53-dependent promoter [1]. Tenovin-6 inhibits the growth of S. cerevisiae cultures with an IC50 of 30 μM and is more toxic to yeast than the less water-soluble tenovin-1.in vivo: Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts [1].

Reference

[1]. Lain S, Hollick JJ, Campbell J, Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.