Teneligliptin hydrobromide

• CAT Number: I005415
• CAS Number: 906093-29-6
• Molecular Formula: C44H65Br5N12O2S2
• Molecular Weight: 1257.72
• Purity: ≥95%
• Target: DPP-4
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 1 nM
• IUPAC Name: [(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone;pentahydrobromide
• InChI: InChI=1S/2C22H30N6OS.5BrH/c2*1-17-13-21(28(24-17)18-5-3-2-4-6-18)26-9-7-25(8-10-26)19-14-20(23-15-19)22(29)27-11-12-30-16-27;;;;;/h2*2-6,13,19-20,23H,7-12,14-16H2,1H3;5*1H/t2*19-,20-;;;;;/m00...../s1
• InChIKey: LUXIOMHUGCXFIU-MAYGPZJUSA-N
• SMILES: CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5.CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5.Br.Br.Br.Br.Br

Teneligliptin hydrobromide (CAT: I005415) is a potent and long-lasting dipeptidyl peptidase-4 (DPP-4) inhibitor. By competitively inhibiting the DPP-4 enzyme, teneligliptin increases the levels of incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). This pharmacological action helps regulate blood glucose levels and improves glycemic control in patients with type 2 diabetes mellitus. Teneligliptin is specifically designed to target DPP-4, making it a valuable drug for the management of diabetes.

Reference

[1]. Fukuda-Tsuru S, et al. A novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor, teneligliptin, improves postprandial hyperglycemia and dyslipidemia after single and repeated administrations. Eur J Pharmacol. 2012 Dec 5;696(1-3):194-202.
[2]. Fukuda-Tsuru S, et al. The novel dipeptidyl peptidase-4 inhibitor teneligliptin prevents high-fat diet-induced obesity accompanied with increased energy expenditure in mice. Eur J Pharmacol. 2014 Jan 15;723:207-15.