Teloxantrone

• CAT Number: I009744
• CAS Number: 91441-48-4
• Molecular Formula: C21H25N5O4
• Molecular Weight: 411.462
• Purity: ≥95%
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• InChI: InChI=1S/C21H25N5O4/c1-22-6-7-24-12-2-3-13-17-16(12)21(30)19-15(29)5-4-14(28)18(19)20(17)25-26(13)10-8-23-9-11-27/h2-5,22-25,27,30H,6-11H2,1H3
• InChIKey: QDZIHWBJFUNKOF-UHFFFAOYSA-N
• SMILES: CNCCNC1=C2C3=C(C=C1)N(NC3=C4C(=O)C=CC(=O)C4=C2O)CCNCCO

Teloxantrone(Cat No.:I009744) is an anthrapyrazole antineoplastic antibiotic. Teloxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair, as well as RNA and protein synthesis.

Reference

1:A phase II study of DuP 937 (Teloxantrone) in metastatic malignant melanoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCICCTG). Shore T, Eisenhauer E, Quirt I, Belanger K, Lohmann R, Silver H, Wielgosz G.Ann Oncol. 1993 Sep;4(8):695-6. No abstract available. PMID: 8241003 2:A phase II trial of DuP 937 (Teloxantrone) in non-small cell lung cancer. A study of the NCIC Clinical Trials Group. Gregg RW, Kaizer L, Fine S, Gelmon K, Wielgosz G, Eisenhauer E.Ann Oncol. 1993 Sep;4(8):693-4. No abstract available. PMID: 8241002 3:Phase II study on DuP 937 (Teloxantrone) in colorectal carcinoma. A Canadian National Cancer Institute Clinical Trial Group study. Maroun JA, Skillings J, MacCormick R, Potvin M, Wielgosz G, Davidson JR, Eisenhauer E.Invest New Drugs. 1993 May-Aug;11(2-3):235-7. No abstract available. PMID: 8262739