Telmisartan

• CAT Number: A000384
• CAS Number: 144701-48-4
• Molecular Formula: C33H30N4O2
• Molecular Weight: 514.6
• Purity: ≥95%
• Target: RAAS
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: 1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
• InChIKey: RMMXLENWKUUMAY-UHFFFAOYSA-N
• SMILES: CCCC1=NC2=C(C=C(C=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C5=NC6=CC=CC=C6N5C)C

Telmisartan is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension.

Reference

1: Sengupta P, Chatterjee B, Pal TK. Assessment of preclinical pharmacokinetics
and acute toxicity of pioglitazone and telmisartan combination. Regul Toxicol
Pharmacol. 2017 Oct 28;91:151-158. doi: 10.1016/j.yrtph.2017.10.029. [Epub ahead
of print] PubMed PMID: 29107617.

2: Li J, Chen H, Zhou Q, Hu L, Ma L, Han H, Li W, Du R, Tian L. Effects of
telmisartan on paroxysmal atrial fibrillation in hypertensive patients. Pak J
Pharm Sci. 2017 Sep;30(5):1651-1655. PubMed PMID: 29084686.

3: Kalikar M, Nivangune KS, Dakhale GN, Bajait CS, Sontakke SD, Motghare VM,
Budania R. Efficacy and Tolerability of Olmesartan, Telmisartan, and Losartan in
Patients of Stage I Hypertension: A Randomized, Open-label Study. J Pharmacol
Pharmacother. 2017 Jul-Sep;8(3):106-111. doi: 10.4103/jpp.JPP_39_17. PubMed PMID:
29081617; PubMed Central PMCID: PMC5642122.

4: Samukawa E, Fujihara S, Oura K, Iwama H, Yamana Y, Tadokoro T, Chiyo T,
Kobayashi K, Morishita A, Nakahara M, Kobara H, Mori H, Okano K, Suzuki Y, Himoto
T, Masaki T. Angiotensin receptor blocker telmisartan inhibits cell proliferation
and tumor growth of cholangiocarcinoma through cell cycle arrest. Int J Oncol.
2017 Dec;51(6):1674-1684. doi: 10.3892/ijo.2017.4177. Epub 2017 Oct 23. PubMed
PMID: 29075786.

5: Li Y, Cheng KC, Liu KF, Peng WH, Cheng JT, Niu HS. Telmisartan Activates PPARδ
to Improve Symptoms of Unpredictable Chronic Mild Stress-Induced Depression in
Mice. Sci Rep. 2017 Oct 25;7(1):14021. doi: 10.1038/s41598-017-14265-4. PubMed
PMID: 29070884; PubMed Central PMCID: PMC5656622.

6: Oura K, Tadokoro T, Fujihara S, Morishita A, Chiyo T, Samukawa E, Yamana Y,
Fujita K, Sakamoto T, Nomura T, Yoneyama H, Kobara H, Mori H, Iwama H, Okano K,
Suzuki Y, Masaki T. Telmisartan inhibits hepatocellular carcinoma cell
proliferation in vitro by inducing cell cycle arrest. Oncol Rep. 2017
Nov;38(5):2825-2835. doi: 10.3892/or.2017.5977. Epub 2017 Sep 20. PubMed PMID:
29048654.

7: Zhang QZ, Liu YL, Wang YR, Fu LN, Zhang J, Wang XR, Wang BM. Effects of
telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in
rats with non-alcoholic fatty liver disease. Exp Ther Med. 2017
Sep;14(3):2689-2694. doi: 10.3892/etm.2017.4809. Epub 2017 Jul 19. PubMed PMID:
28962213; PubMed Central PMCID: PMC5609203.

8: Kato Y, Mukai Y, Rane A, Inotsume N, Toda T. Combined effect of telmisartan
and fluvastatin on arachidonic acid metabolism in human liver microsomes.
Xenobiotica. 2017 Oct 13:1-6. doi: 10.1080/00498254.2017.1384079. [Epub ahead of
print] PubMed PMID: 28933256.

9: Kato Y, Mukai Y, Rane A, Inotsume N, Toda T. The Inhibitory Effect of
Telmisartan on the Metabolism of Arachidonic Acid by CYP2C9 and CYP2C8: An in
Vitro Study. Biol Pharm Bull. 2017;40(9):1409-1415. doi: 10.1248/bpb.b17-00174.
PubMed PMID: 28867723.

10: Fan X, Song X, Zhao M, Jarskog LF, Natarajan R, Shukair N, Freudenreich O,
Henderson DC, Goff DC. The effect of adjunctive telmisartan treatment on
psychopathology and cognition in patients with schizophrenia. Acta Psychiatr
Scand. 2017 Nov;136(5):465-472. doi: 10.1111/acps.12799. Epub 2017 Aug 29. PubMed
PMID: 28851055; PubMed Central PMCID: PMC5630515.