Tedizolid - CAS 856866-72-3

Tedizolid (CAT: I005141) is an oxazolidinone antibiotic used for the treatment of bacterial infections. It is a second-generation derivative of linezolid with improved pharmacokinetic properties. Tedizolid inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, specifically targeting the 23S rRNA. It exhibits potent activity against a broad spectrum of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE). Tedizolid has been approved for use in the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible bacteria.

Catalog Number: I005141

CAS Number: 856866-72-3

PubChem Substance ID:355040352

Molecular Formula: C17H15FN6O3

Molecular Weight:370.34

Purity: 98.0%

Appearance:Solid powder

* For research use only. Not for human or veterinary use.

Synonym

Synonyms(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one

Property

Molecular Formula: C17H15FN6O3
Molecular Weight370.34
Target:Antibiotic
Solubility10 mM in DMSO
Purity98.0%
StorageStore at -20°C
Overview of Clinical ResearchTorezolid is an ribosomal protein inhibitor.&nbsp;<span style=”font-family:arial,helvetica,sans-serif;”><span style=”font-size:12px;”><span style=”font-variant-ligatures: normal; orphans: 2; widows: 2;”>Tedizolid licensed to Nabriva Therapeutics in USA.</span></span></span>
IC508.7 μM(MAO-A); 5.7 μM(MAO-B)

Computed Descriptor

IUPAC Name(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
InChIInChI=1S/C17H15FN6O3/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(9-25)27-17(24)26/h2-7,12,25H,8-9H2,1H3/t12-/m1/s1
InChIKeyXFALPSLJIHVRKE-GFCCVEGCSA-N
SMILESCN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4CC(OC4=O)CO)F