Teclozan

• CAT Number: I037078
• CAS Number: 5560-78-1
• Molecular Formula: C20H28Cl4N2O4
• Molecular Weight: 502.25
• Purity: 98%
• Solubility: Soluble in DMSO
• Storage: 4°C, protect from light
• IUPAC Name: 2,2-dichloro-N-[[4-[[(2,2-dichloroacetyl)-(2-ethoxyethyl)amino]methyl]phenyl]methyl]-N-(2-ethoxyethyl)acetamide
• InChI: InChI=1S/C20H28Cl4N2O4/c1-3-29-11-9-25(19(27)17(21)22)13-15-5-7-16(8-6-15)14-26(10-12-30-4-2)20(28)18(23)24/h5-8,17-18H,3-4,9-14H2,1-2H3
• InChIKey: MSJLJWCAEPENBL-UHFFFAOYSA-N
• SMILES: CCOCCN(CC1=CC=C(C=C1)CN(CCOCC)C(=O)C(Cl)Cl)C(=O)C(Cl)Cl

Teclozan（Cat No.:I037078）, also referred to as WIN 13146, is an antiprotozoal agent used to combat certain types of parasitic infections. It belongs to the dichloroacetamide class of compounds. Teclozan demonstrates efficacy against various protozoa, including Entamoeba histolytica and Giardia lamblia, by interfering with their metabolic pathways. By targeting these parasites, Teclozan helps to alleviate the symptoms and combat the infections caused by these protozoa.

Reference

1: Antiamoebic drugs for treating amoebic colitis Maria Liza M Gonzales, Leonila F Dans, Juliet Sio‐Aguilar
Cochrane Database Syst Rev. 2019 Jan; 2019(1): CD006085. Published online 2019 Jan 9. doi: 10.1002/14651858.CD006085.pub3 PMCID: PMC6326239
2: Intestinal parasites. R Knight, M G Schultz, D W Hoskins, P D Marsden Gut. 1973 Feb; 14(2): 145–168. doi: 10.1136/gut.14.2.145 PMCID: PMC1412563
3: Comparative genomics identifies potential virulence factors in Clostridium tertium and C. paraputrificum Marina Muñoz, Daniel Restrepo-Montoya, Nitin Kumar, Gregorio Iraola, Giovanny Herrera, Dora I. Ríos Chaparro, Diana Díaz-Arévalo, Manuel A. Patarroyo, Trevor D. Lawley, Juan David Ramírez Virulence. 2019; 10(1): 657–676. Published online 2019 Jul 13. doi: 10.1080/21505594.2019.1637699 PMCID: PMC6629180
4: Parasite-related diarrhoeas WHO Scientific Working Group Bull World Health Organ. 1980; 58(6): 819–830.
PMCID: PMC2396014
5: Flavonoids as a Natural Treatment Against Entamoeba histolytica Moisés Martínez-Castillo, Judith Pacheco-Yepez, Nadia Flores-Huerta, Paula Guzmán-Téllez, Rosa A. Jarillo-Luna, Luz M. Cárdenas-Jaramillo, Rafael Campos-Rodríguez, Mineko Shibayama Front Cell Infect Microbiol. 2018; 8: 209. Published online 2018 Jun 22. doi: 10.3389/fcimb.2018.00209 PMCID: PMC6024094
6: Availability of essential medicines in primary health care of the Brazilian Unified Health System Renata Cristina Rezende Macedo do Nascimento, Juliana Álvares, Augusto Afonso Guerra, Junior, Isabel Cristina Gomes, Ediná Alves Costa, Silvana Nair Leite, Karen Sarmento Costa, Orlando Mario Soeiro, Ione Aquemi Guibu, Margô Gomes de Oliveira Karnikowski, Francisco de Assis Acurcio Rev Saude Publica. 2017; 51(Suppl 2): 10s.
Published online 2017 Sep 22. doi: 10.11606/S1518-8787.2017051007062 PMCID: PMC5676352