TDI-10229

• CAT Number: I045386
• CAS Number: 2810887-45-5
• Molecular Formula: C16H16ClN5
• Molecular Weight: 313.78
• Purity: ≥95%
• Synonyms: 4-(4-benzyl-1,5-dimethylpyrazol-3-yl)-6-chloropyrimidin-2-amine
• InChI: InChI=1S/C16H16ClN5/c1-10-12(8-11-6-4-3-5-7-11)15(21-22(10)2)13-9-14(17)20-16(18)19-13/h3-7,9H,8H2,1-2H3,(H2,18,19,20)
• InChIKey: VSMTYSWGHKYXOF-UHFFFAOYSA-N
• SMILES: CC1=C(C(=NN1C)C2=CC(=NC(=N2)N)Cl)CC3=CC=CC=C3

TDI-10229 (Cat No.: I045386) is a selective small-molecule inhibitor of soluble adenylyl cyclase (sAC), an enzyme that produces cyclic AMP (cAMP) in response to bicarbonate and calcium signals. By blocking sAC activity, TDI-10229 disrupts cAMP-mediated signaling pathways involved in sperm motility and capacitation, making it a promising candidate for non-hormonal male contraception. It is primarily used in preclinical research to study reproductive biology and the role of sAC in cellular signaling, with potential applications in fertility control and other cAMP-related physiological processes.

Reference

[1]. Balbach M, et al. Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization [published online ahead of print, 2021 Aug 31]. Mol Hum Reprod. 2021;gaab054.
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[2]. Fushimi M, et al. Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). ACS Med Chem Lett. 2021;12(8):1283-1287. Published 2021 Jul 14.
[Content Brief]