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LM22B-10

LM22B-10

  • CAT Number: I013178
  • CAS Number: 342777-54-2
  • Molecular Formula: C₂₇H₃₃ClN₂O₄
  • Molecular Weight: 485.01
  • Purity: ≥95%
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LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.

Catalog Number I013178
CAS Number 342777-54-2
Molecular Formula

C₂₇H₃₃ClN₂O₄

Purity 95%
Target Trk Receptor Akt ERK
Solubility DMSO: ≥ 150 mg/mL
IUPAC Name 2-[4-[[4-[bis(2-hydroxyethyl)amino]phenyl]-(4-chlorophenyl)methyl]-N-(2-hydroxyethyl)anilino]ethanol
InChI InChI=1S/C27H33ClN2O4/c28-24-7-1-21(2-8-24)27(22-3-9-25(10-4-22)29(13-17-31)14-18-32)23-5-11-26(12-6-23)30(15-19-33)16-20-34/h1-12,27,31-34H,13-20H2
InChIKey QCXQLSGBOUUVNH-UHFFFAOYSA-N
SMILES C1=CC(=CC=C1C(C2=CC=C(C=C2)N(CCO)CCO)C3=CC=C(C=C3)Cl)N(CCO)CCO
Reference

[1]. Yang T, et al. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. 2016 Nov;110(Pt A):343-61.

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