TCS 401

• CAT Number: I002818
• CAS Number: 243966-09-8
• Molecular Formula: C10H11ClN2O5S
• Molecular Weight: 306.717
• Purity: ≥95%
• Solubility: DMSO ≥ 11 mg/mL
• Storage: -20°C
• IUPAC Name: 2-(oxaloamino)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid;hydrochloride
• InChI: InChI=1S/C10H10N2O5S.ClH/c13-7(10(16)17)12-8-6(9(14)15)4-1-2-11-3-5(4)18-8;/h11H,1-3H2,(H,12,13)(H,14,15)(H,16,17);1H
• InChIKey: LQGCAMWQDSYOAY-UHFFFAOYSA-N
• SMILES: C1CNCC2=C1C(=C(S2)NC(=O)C(=O)O)C(=O)O.Cl

TCS 401 (CAT: I002818) is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B is an enzyme involved in the dephosphorylation of tyrosine residues in proteins, regulating various cellular processes including insulin signaling, metabolism, and cell growth. By inhibiting PTP1B, TCS 401 prevents the dephosphorylation of target proteins, leading to enhanced signaling and modulation of cellular pathways. This selective inhibition of PTP1B by TCS 401 may have potential therapeutic applications in diseases such as diabetes and obesity, where dysregulation of insulin signaling is implicated.

Reference

[1]. Du ZD, et al. Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. Mol Vis. 2015 May 1;21:523-31.

[2]. Ponnusamy M, et al. Necrotic renal epithelial cell inhibits renal interstitial fibroblast activation: role of protein tyrosine phosphatase 1B. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F698-709.