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TCS 359

TCS 359

  • CAT Number: I003049
  • CAS Number: 301305-73-7
  • Molecular Formula: C18H20N2O4S
  • Molecular Weight: 360.4
  • Purity: ≥95%
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TCS 359 (Cat.No:I003049), a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. TCS 359 inhibits MV4-11 proliferation with IC50 of 340 nM. TCS 359 is highly selective for FLT3 against a panel of kinases .

Catalog Number I003049
CAS Number 301305-73-7
Molecular Formula

C18H20N2O4S

Purity 95%
Target FLT3
Solubility DMSO 15 mg/mL; Water <1 mg/mL; Ethanol<1 mg/mL
Storage 3 years -20℃ powder
IC50 42 nM [1]
IUPAC Name 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
InChI InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)
InChIKey FSPQCTGGIANIJZ-UHFFFAOYSA-N
SMILES COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC
Reference

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<br>[1]. Patch RJ, et al. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3282-6.
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