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TCMDC-135051

TCMDC-135051

  • CAT Number: I018089
  • CAS Number: 2413716-15-9
  • Molecular Formula: C₂₉H₃₃N₃O₃
  • Molecular Weight: 471.59
  • Purity: ≥95%
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TCMDC-135051 (Cat.No:I018089) is a highly selective and potent protein kinase PfCLK3 inhibitor with low off-target toxicity. TCMDC-135051 prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 has antiparasiticidal activity (EC50=320 nM)[1].<br>TCMDC-135051 shows potent activity against P. berghei sporozoites in a liver invasion and development assay in which the compound shows a pEC50 value of 6.17 (EC50=0.40 μM).

Catalog Number I018089
CAS Number 2413716-15-9
Molecular Formula

C₂₉H₃₃N₃O₃

Purity 95%
Reference

[1]. Alam MM, et al. Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science. 2019 Aug 30;365(6456). pii: eaau1682.

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