TC-DAPK 6

• CAT Number: I003122
• CAS Number: 315694-89-4
• Molecular Formula: C17H12N2O2
• Molecular Weight: 276.29
• Purity: ≥95%
• Target: DAPK
• Solubility: Soluble to 50 mM in DMSO
• Storage: Store at -20°C
• IC50: 69 nM (DAPK1); 225 nM (DAPK3)

TC-DAPK 6 is an oxazalone compound that acts as a potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor (IC50 = 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 uM ATP).IC50 value: 69 nM (DAPK1); 225 nM (DAPK3)Target: DAPK1; DAPK3Death-associated protein kinase (DAPK) is a serine/threonine protein kinase implicated in diverse programmed cell death pathways. DAPK is a promising target protein for the treatment of ischemic diseases. TC-DAPK 6 is an oxazalone compound that acts as a potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor (IC50 = 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 uM ATP); while exhibiting much reduced or no activity against a panel of 48 other kinases even at concentrations as high as 10 uM.

Reference

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