TBK1/IKKε-IN-5

• CAT Number: I018956
• CAS Number: 1893397-65-3
• Molecular Formula: C₂₈H₃₁N₇O₃
• Molecular Weight: 513.59
• Purity: ≥95%

TBK1/IKKε-IN-5 (CAT: I018956) is a potent inhibitor that targets both TBK1 (TANK-binding kinase 1) and IKKε (IκB kinase epsilon). TBK1 and IKKε are serine/threonine kinases that play critical roles in innate immune response signaling pathways. By inhibiting both TBK1 and IKKε, compound 1 interferes with the activation of downstream signaling cascades involved in inflammatory and antiviral responses. This dual inhibition has potential therapeutic implications in various diseases associated with aberrant immune responses, including autoimmune disorders and certain viral infections.

Reference

[1]. Jenkins RW, et al. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov. 2018 Feb;8(2):196-215.