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TB5

TB5

  • CAT Number: I009722
  • CAS Number: 948841-07-4
  • Molecular Formula: C15H14BrNOS
  • Molecular Weight: 336.2
  • Purity: ≥95%
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TB5 (Cat.No:I009722) is a MAO-B inhibitor. TB5 showed the inhibitory activity and selectivity toward hMAO-B, with Ki and SI values of 0.11±0.01 μm and 13.18, respectively. TB5 was found to be nontoxic at 5 and 25 μm, with 95.75 and 84.59 % viability among cells, respectively.

Catalog Number I009722
CAS Number 948841-07-4
Molecular Formula

C15H14BrNOS

Purity 95%
Target MAO-B inhibitor
Solubility Soluble in DMSO
Storage Store at -20°C
IUPAC Name (E)-1-(5-bromothiophen-2-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one
InChI InChI=1S/C15H14BrNOS/c1-17(2)12-6-3-11(4-7-12)5-8-13(18)14-9-10-15(16)19-14/h3-10H,1-2H3/b8-5+
InChIKey PTLDLBSWTKNYCY-VMPITWQZSA-N
SMILES CN(C)C1=CC=C(/C=C/C(C2=CC=C(Br)S2)=O)C=C1
Reference

</br>1: Mathew B, Haridas A, Uçar G, Baysal I, Joy M, Mathew GE, Lakshmanan B, Jayaprakash V. Synthesis, Biochemistry, and Computational Studies of Brominated Thienyl Chalcones: A New Class of Reversible MAO-B Inhibitors. ChemMedChem. 2016 Jun 6;11(11):1161-71. doi: 10.1002/cmdc.201600122. PubMed PMID: 27159243.

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