Tariquidar methanesulfonate, hydrate

• CAT Number: I004360
• CAS Number: 625375-83-9
• Molecular Formula: C40H52N4O15S2
• Molecular Weight: 892.99
• Purity: ≥95%
• Synonyms: N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide;methanesulfonic acid;trihydrate
• Target: P-gp
• Solubility: 5.35 mg/mL ＜ H2O ＜ 8.9 mg/mL
• Storage: Store at -20°C
• IC50: 5.1 nM (Kd) [1]

Tariquidar methanesulfonate, hydrate (Cat.No:I004360) is a chemical compound used as a P-glycoprotein (P-gp) inhibitor. P-gp is a membrane transporter that plays a role in drug resistance. Tariquidar methanesulfonate, hydrate has shown potential in preclinical studies for reversing multidrug resistance in cancer cells, enhancing the effectiveness of chemotherapy treatments.

Reference

[1]. Martin C, et al. The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein. Br J Pharmacol, 1999, 128(2), 403-411.
[2]. Robey RW, et al. Pheophorbide a is a specific probe for ABCG2 function and inhibition. Cancer Res, 2004, 64(4), 1242-1246.
[3]. Mistry P, et al. In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576. Cancer Res, 2001, 61(2), 749-758.