Targapremir-210

• CAT Number: I020175
• CAS Number: 1049722-30-6
• Molecular Formula: C₃₂H₃₆N₁₀O₂
• Molecular Weight: 592.69
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: N-(3-azidopropyl)-4-[3-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenoxy]butanamide
• InChI: InChI=1S/C32H36N10O2/c1-41-14-16-42(17-15-41)24-9-11-27-29(21-24)39-32(37-27)23-8-10-26-28(20-23)38-31(36-26)22-5-2-6-25(19-22)44-18-3-7-30(43)34-12-4-13-35-40-33/h2,5-6,8-11,19-21H,3-4,7,12-18H2,1H3,(H,34,43)(H,36,38)(H,37,39)
• InChIKey: PAYVJEWMAWLKAP-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC(=CC=C6)OCCCC(=O)NCCCN=[N+]=[N-]

Targapremir-210 (Cat No.:I020175) is a highly potent and selective inhibitor of miR-210, a microRNA involved in various biological processes. It specifically targets the processing of pre-miR-210 with high affinity, demonstrated by a binding affinity (Kd) of approximately 200 nM. By inhibiting miR-210, Targapremir-210 modulates the expression and activity of this microRNA, potentially impacting downstream gene regulation and cellular pathways.

Reference

[1]. Costales MG, et al. Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. J Am Chem Soc. 2017 Mar 8; 139(9):3446-3455.