Tanshinone IIA-Sulfonic Sodium

• CAT Number: I004615
• CAS Number: 69659-80-9
• Molecular Formula: C₁₉H₁₇NaO₆S
• Molecular Weight: 396.39
• Purity: ≥95%
• Target: SOCE
• Solubility: Water
• Storage: 3 years -20C powder
• InChI: InChI=1S/C19H18O6S.Na/c1-9-13-15(20)16(21)14-10-5-4-8-19(2,3)12(10)7-6-11(14)17(13)25-18(9)26(22,23)24;/h6-7H,4-5,8H2,1-3H3,(H,22,23,24);/q;+1/p-1
• InChIKey: AZEZEAABTDXEHR-UHFFFAOYSA-M
• SMILES: CC1=C(OC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C)S(=O)(=O)[O-].[Na+]

Tanshinone IIA-sulfonic sodium(CAT: I004615) represents a significant advancement in pharmacological research, particularly in the context of cardiovascular disorders. As a water-soluble derivative of tanshinone IIA, this compound exhibits distinctive properties that contribute to its therapeutic potential. Tanshinone IIA-sulfonic sodium functions as an inhibitor of store-operated Ca2+ entry (SOCE), a process crucial for calcium homeostasis and cellular functions. By modulating SOCE, it holds promise in addressing conditions related to cardiovascular health. This compound’s application as a treatment for cardiovascular disorders underscores its importance in advancing strategies for managing heart-related conditions.

Reference

[1]. Xu QQ, et al. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. Biomed Res Int. 2016;2016:9852536.

[2]. Jiang Q, et al. Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis. Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C136-49.

[3]. Ouyang DS, et al. Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro. Chin Med. 2016 Mar 22;11:11.

[4]. Chen D, et al. Sodium tanshinone IIA sulfonate and its interactions with human CYP450s. Xenobiotica. 2016 Dec;46(12):1085-1092. Epub 2016 Mar 2.

[5]. Lin S, et al. [Sodium tanshinone IIA sulfonate prevents postoperative peritoneal adhesions in rats by enhancing the activity of the peritoneal fibrinolytic system]. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb;36(2):260-4.