Tanshinone I

• CAT Number: I004122
• CAS Number: 568-73-0
• Molecular Formula: C18H12O3
• Molecular Weight: 276.291
• Purity: ≥95%
• Target: 11 μM (sPLA2), 82 μM(cPLA2)
• Solubility: DMSO
• Storage: 3 years -20C powder
• IUPAC Name: 1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione
• InChI: InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
• InChIKey: AIGAZQPHXLWMOJ-UHFFFAOYSA-N
• SMILES: CC1=CC=CC2=C1C=CC3=C2C(=O)C(=O)C4=C3OC=C4C

Tanshinone I(CAT: I004122) is a natural compound that acts as an inhibitor of type IIA human recombinant sPLA2 (secretory phospholipase A2) with an IC50 of 11 μM. This compound also demonstrates inhibitory activity against rabbit recombinant cPLA2 (cytosolic phospholipase A2). sPLA2 and cPLA2 enzymes play roles in lipid metabolism and the release of arachidonic acid, which is a precursor to various inflammatory mediators. Tanshinone I’s ability to inhibit these enzymes suggests its potential as an anti-inflammatory agent, making it a candidate for further exploration in the context of inflammatory conditions and related diseases.

Reference

[1]. Kim SY, et al. Effects of Tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses. Phytother Res. 2002 Nov;16(7):616-20.