Tandospirone citrate

• CAT Number: I000471
• CAS Number: 112457-95-1
• Molecular Formula: C27H37N5O9
• Molecular Weight: 575.61
• Purity: ≥95%
• Target: 5-HT1A
• Solubility: 10 mM in DMSO
• Storage: 3 years -20℃ powder
• IC50: 27±5 nM(Ki) [1]
• IUPAC Name: 2-hydroxypropane-1,2,3-tricarboxylic acid;(1S,2R,6S,7R)-4-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-4-azatricyclo[5.2.1.02,6]decane-3,5-dione
• InChI: InChI=1S/C21H29N5O2.C6H8O7/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h3,6-7,15-18H,1-2,4-5,8-14H2;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t15-,16+,17+,18-
• InChIKey: DMLGUJHNIWGCKM-DPFKZJTMSA-N
• SMILES: C1CC2CC1C3C2C(=O)N(C3=O)CCCCN4CCN(CC4)C5=NC=CC=N5.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Tandospirone citrate (Cat.No:I000471) is a medication used primarily in the treatment of anxiety disorders and depression. It acts as a selective serotonin 5-HT1A receptor partial agonist, exerting anxiolytic and antidepressant effects. Tandospirone citrate is well-tolerated and offers an alternative treatment option for individuals with anxiety and mood disorders.

Reference

[1]. Hamik A, et al. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol Psychiatry. 1990 Jul 15;28(2):99-109.

[2]. Shimizu H, et al. Characterization of the putative anxiolytic SM-3997 recognition sites in rat brain. Life Sci. 1988;42(24):2419-27.

[3]. Uehara T, et al. Chronic treatment with tandospirone, a 5-HT1A receptor partial agonist, suppresses footshock stress-induced lactate production in the prefrontal cortex of rats. Pharmacol Biochem Behav. 2013 Nov 15;113:1-6.

[4]. Ohmura Y, et al. Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor. J Pharmacol Sci. 2013;122(2):84-92.