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TAME

TAME

  • CAT Number: A000821
  • CAS Number: 901-47-3
  • Molecular Formula: C14H22N4O4S
  • Molecular Weight: 342.41
  • Purity: ≥95%
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Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.<br>TAME inhibits cyclin proteolysis in mitotic Xenopus egg extract with IC50 of 12 µM. TAME at concentration of 1-200 μM arrests interphase extract treated with recombinant cyclin B1/Cdc2 complex in mitosis, with stable cyclin B1 and phosphorylated Cdc27. TAME at concentration of 200 μM dramaticly inhibits the ubiquitin ligase activity of the Anaphase-Promoting Complex (APC), accompanied by reduced binding of Cdh1 to APC. TAME addition to interphase extract reduces Cdc20 association with the APC in a dose-dependent manner partly by binding directly to APC, and the contribution motif is the C-terminal isoleucine-arginine (IR) tail on APC.

Catalog Number A000821
CAS Number 901-47-3
Molecular Formula

C14H22N4O4S

Purity 95%
Target APC
Storage 3 years -20C powder

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