Taccalonolide A

• CAT Number: M137150
• CAS Number: 108885-68-3
• Molecular Formula: C36H46O14
• Molecular Weight: 702.75
• Purity: ≥95%
• Storage: -20°C
• IUPAC Name: [(1S,2S,3R,5S,7S,9S,10R,11R,12S,13S,14R,15R,16S,17S,22S,23S,24R,25R)-10,14,25-triacetyloxy-3,22-dihydroxy-11,15,17,22,23-pentamethyl-4,21-dioxo-8,20-dioxaheptacyclo[13.10.0.02,12.05,11.07,9.016,24.019,23]pentacos-18-en-13-yl] acetate
• InChI: InChI=1S/C36H46O14/c1-12-10-19-35(8,36(9,44)32(43)50-19)24-21(12)34(7)22(28(24)45-13(2)37)20-23(29(46-14(3)38)31(34)48-16(5)40)33(6)17(25(41)26(20)42)11-18-27(49-18)30(33)47-15(4)39/h10,12,17-18,20-24,26-31,42,44H,11H2,1-9H3/t12-,17-,18+,20+,21+,22-,23-,24+,26-,27+,28-,29+,30+,31+,33+,34-,35+,36-/m1/s1
• InChIKey: PTTJLTMUKRRHAT-VJAKQJMOSA-N
• SMILES: CC1C=C2C(C3C1C4(C(C3OC(=O)C)C5C(C(C4OC(=O)C)OC(=O)C)C6(C(CC7C(C6OC(=O)C)O7)C(=O)C5O)C)C)(C(C(=O)O2)(C)O)C

Taccalonolide A（Cat No.:702.75） is a steroid compound derived from Taccachantryeri, possessing cytotoxic and antimalarial properties. As a microtubule stabilizer, it induces G2-M cell cycle arrest, phosphorylates Bcl-2, and triggers apoptosis. Taccalonolide A shows notable efficacy against cell lines overexpressing p-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7) in vitro, making it a potential candidate for overcoming drug resistance in cancer treatment. With an IC50 value of 622nM, Taccalonolide A exhibits significant growth inhibition in SK-OV-3 cells, highlighting its potential as a valuable therapeutic agent for cancer and antimalarial research.