TA-01

• CAT Number: I002312
• CAS Number: 1784751-18-3
• Molecular Formula: C₂₀H₁₂F₃N₃
• Molecular Weight: 351.32
• Purity: ≥95%
• Target: HSC
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 6.4/6.8/6.7 nM
• IUPAC Name: 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine
• InChI: InChI=1S/C20H12F3N3/c21-14-6-4-12(5-7-14)18-19(13-8-10-24-11-9-13)26-20(25-18)17-15(22)2-1-3-16(17)23/h1-11H,(H,25,26)
• InChIKey: TWPJJJZCYVFUOA-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C(=C1)F)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)F

TA-01 (Cat No.:I002312) is a small molecule inhibitor of the transforming growth factor-beta (TGF-β) pathway. It binds to the transcription factor forkhead box protein O4 (FoxO4) and prevents its phosphorylation, leading to increased nuclear localization and activation of FoxO4. This, in turn, promotes the transcription of target genes involved in TGF-β signaling, such as Smad7. TA-01 has been shown to inhibit TGF-β-induced epithelial-to-mesenchymal transition (EMT) in cancer cells and reduce fibrosis in animal models. It has potential therapeutic applications in cancer and fibrotic diseases.

Reference

[1]. Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar;80:56-70.