T16Ainh-A01

• CAT Number: I011849
• CAS Number: 552309-42-9
• Molecular Formula: C19H20N4O3S2
• Molecular Weight: 416.514
• Purity: ≥95%
• Target: Chloride Channels
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at +4°C
• IUPAC Name: 2-[(5-ethyl-6-methyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]acetamide
• InChI: InChI=1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)
• InChIKey: QSIYTNYMBWYHAA-UHFFFAOYSA-N
• SMILES: CCC1=C(NC(=NC1=O)SCC(=O)NC2=NC(=CS2)C3=CC=C(C=C3)OC)C

T16Ainh-A01 (CAT: I011849) is a selective inhibitor of the calcium-activated chloride channel TMEM16A (also known as ANO1). It blocks the activity of TMEM16A by directly binding to the channel protein, thereby inhibiting chloride ion transport. TMEM16A channels are involved in various physiological processes, including smooth muscle contraction, regulation of electrical excitability, and secretion of fluids. By specifically targeting TMEM16A, T16Ainh-A01 has been studied for its potential therapeutic applications in conditions such as cystic fibrosis, hypertension, and cancer, where aberrant TMEM16A function plays a role. T16Ainh-A01 offers a valuable tool to investigate the physiological and pathological roles of TMEM16A channels and may have future clinical applications.

Reference

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N-aroylaminothiazole and capsaicin and inhibition by T16A[inh]-A01. Mol Pain.
2015 Sep 12;11:55. doi: 10.1186/s12990-015-0061-y. PubMed PMID: 26364309; PubMed
Central PMCID: PMC4567824.
2: Boedtkjer DM, Kim S, Jensen AB, Matchkov VM, Andersson KE. New selective
inhibitors of calcium-activated chloride channels – T16A(inh) -A01, CaCC(inh)
-A01 and MONNA – what do they inhibit? Br J Pharmacol. 2015 Aug;172(16):4158-72.
doi: 10.1111/bph.13201. Epub 2015 Jul 8. PubMed PMID: 26013995; PubMed Central
PMCID: PMC4543620.
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Verkman AS, Albert AP, Greenwood IA. Potent vasorelaxant activity of the TMEM16A
inhibitor T16A(inh) -A01. Br J Pharmacol. 2013 Feb;168(3):773-84. doi:
10.1111/j.1476-5381.2012.02199.x. PubMed PMID: 22946562; PubMed Central PMCID:
PMC3579294.